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As a result, the metabolite is chargeable for about twenty% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly while in the feces (about 80% of administered oral dose) and also to a lesser extent while in the urine (all around 13% on the administered oral dose). If taken which has a higher-Unwanted fat food, absorption is diminished; enough time taken to reach the utmost plasma concentration boosts by all around a person hour, and the maximum concentration by itself is diminished by almost a single-3rd.[52]
Nei pazienti che ricevono medicinali antipertensivi concomitanti, il tadalafil può indurre una riduzione della pressione del sangue.
Tadalafil (20 mg) è stato studiato in associazione a four classi di antipertensivi. Nei soggetti che assumevano più antipertensivi, le variazioni della pressione sanguigna controllata ambulatorialmente apparivano correlabili al grado di controllo della pressione sanguigna. Nei soggetti con pressione sanguigna ben controllata, la riduzione della pressione sanguigna era minima e simile a quella osservata nei soggetti sani.
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